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Dynamic Balance of Internal and External Factors
Important in the application of the Balance Protocol is the idea that lifestyle translates into quantifiable effects on health and disease through the energetics of our biochemistry and genetics. Different activities and emotions; such as eating, exercising or not exercising, joy, pain, and love, for example; are integral to inducing the dynamic mix of molecules that, through the masking and unmasking of chromosome sites, lead to the sum of experiences that our patients identify as their lives.
Environment modifies not only the expression of inducible genes but also post-translational cellular function. After the genes have been expressed and their message has been translated into the manufacture of protein and other cellular materials, the structure and function of these substances can be further altered as a consequence of processes such as oxidation or glycation. Both of these post-translational influences can further alter cellular function in such a way as to be associated with unhealthy aging.
The combination of the environmental effects on both gene expression and post-translational modification of cellular materials gives rise to symptoms of aging that are well recognized in clinical medicine.
For example, individuals who smoke heavily appear to age faster, and they have higher risk of age-related diseases such as cancer and heart disease.Individuals who consume excessive alcohol also appear to age more quickly, and they have increased risk to liver and heart-related problems. Individuals who consume poor quality diets that are excessive in calorie load and low in essential nutrients density, show the signs of over-consumptive under-nutrition with obesity, poor health patterns, and more prevalent age-related diseases.
These examples demonstrate how environment and lifestyle influence gene expression and post-translational modification of cellular function. Medicine has focused principally on the diagnosis of these diseases once they occur, and physicians have historically placed less emphasis on understanding genetic susceptibilities and gene expression modifiers.